Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
Identifieur interne : 007903 ( Main/Exploration ); précédent : 007902; suivant : 007904Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
Auteurs : Panagiotis A. Konstantinopoulos [États-Unis] ; Bruce J. Dezube [États-Unis] ; Liron Pantanowitz [États-Unis]Source :
- BMC Clinical Pathology [ 1472-6890 ] ; 2006.
Abstract
The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions.
We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34.
Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.
Url:
DOI: 10.1186/1472-6890-6-7
PubMed: 17074096
PubMed Central: 1634748
Affiliations:
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Konstantinopoulos</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J" last="Dezube">Bruce J. Dezube</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pantanowitz, Liron" sort="Pantanowitz, Liron" uniqKey="Pantanowitz L" first="Liron" last="Pantanowitz">Liron Pantanowitz</name><affiliation wicri:level="2"><nlm:aff id="I2">Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">BMC Clinical Pathology</title><idno type="eISSN">1472-6890</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions.</p></sec><sec><title>Case Presentation</title><p>We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34.</p></sec><sec><title>Conclusion</title><p>Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Konstantinopoulos, Panagiotis A" sort="Konstantinopoulos, Panagiotis A" uniqKey="Konstantinopoulos P" first="Panagiotis A" last="Konstantinopoulos">Panagiotis A. 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